The approach we take for Integrail is to have a look at the current evidence on what really works to prolong healthspan in humans and provide this to our clients in the most convenient way possible. For this we go through the available studies and importantly aim to stay as well up-to-date on new insights as they become available. So, expect frequent study updates here.
We have set ourselves a few clear principles as we go about this:
- Any intervention we would ultimately short list needs to be based on impact in humans. Animal models can tell a lot but we are ultimately looking forward for impact in humans.
- The first metric we are looking towards for BioAge impact will be epigenetic clocks. While there is certainly anything less than consensus on their validation (see here for a good discussion on concerns brought up in this piece by Peter Attia), the longevity science consensus currently sees them as front-runner as they are getting increasingly further developed and receive increasingly more research support.
- We are as well looking for further scientific data such as for example epidemological data supporting the short listing of a specific intervention.
- As we build our own longitudinal data around interventions, we will update our short list accordingly and obviously provide our data and reasoning along with this.
Importantly, we want to state again that this is work in progress as more research is done. We are looking forward to update this work often and as always welcome your input wherever we might have missed a study worth considering or you suggest improvements to our process – please email to feedback@integrail.health. Only a small minority of interventions will pass our assessment to be short listed. Those that are still in the process of collecting this evidence will be placed in our category “interventions under investigation”. This is basically our long list of interesting intervention candidates. Finally, to all these lists there is as well a whole pipeline of further “interventions in development”. We will start to highlight these as well. They might still be years or even decades away but there is a lot of promise there.
